GPBP1 — GC-rich promoter binding protein 1

GPBP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GPBP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Chromatin Modification DNA/chromatin regulation	AKAP13, CREBRF, EPC1, GCC2, JMJD1C, KMT2E, OFD1, PPP1R2 +6 more	View in SCUBA
CD4⁺ T cells	Chemokine Migration migration & adhesion	CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GNG2, KMT2E, PDE4B +7 more	View in SCUBA
Gamma-delta T cells	AHR/NF-κB Survival Immune regulation	ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more
Innate lymphoid cells	Integrated Stress Response Stress	AMD1, ATF4, CYCS, DDX5, DNAJB6, EIF1, HERPUD1, HNRNPH1 +3 more	View in SCUBA
Lymphatic endothelial	Notch TGF-β Endothelial endothelial development	ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, HEY1 +11 more	View in SCUBA
Macrophages	Autophagy Vesicle Trafficking Lysosomal & pahgocytosis	ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more	View in SCUBA
Mucosal-associated invariant T cell	RUNX3 Tissue Identity T cell maturation	B4GALT1, CD44, CDK17, CHD1, CYLD, EML4, EP300, KMT2E +10 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, PDE4B, PIK3R1, RALGAPA1, SDCBP +4 more	View in SCUBA

About the gene

Synonyms	DKFZp761C169
Chromosome	5: 57173948-57264679
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Function

Functions as a GC-rich promoter-specific transactivating transcription factor

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.