SUPT20H — SPT20 homolog, SAGA complex component
SUPT20H belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUPT20H's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, CLCN3, EDEM3, GART, GOPC, HERC4, KRIT1, LRIF1 +13 more | |
| Mucosal-associated invariant T cell | Epigenetic Maintenance DNA/chromatin regulation | ATAD2B, ATXN10, DENND6A, DGLUCY, DMTF1, FYCO1, GALK2, HDLBP +13 more |
About the gene
| Synonyms | bA421P11.4, C13orf19, FAM48A, P38IP, SPT20 |
|---|---|
| Chromosome | 13: 37009312-37059713 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Autophagy, Gastrulation |
Function
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.