EDEM3 — ER degradation enhancing alpha-mannosidase like protein 3
EDEM3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDEM3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, CLCN3, GART, GOPC, HERC4, KRIT1, LRIF1, PCMTD1 +13 more | |
| Goblet cells | Protein trafficking & glycosylation Mucus production & secretion | COPA, COPB1, COPB2, COPG1, FAM114A1, GALNT3, GALNT7, TM9SF2 +1 more | View in SCUBA |
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10 +19 more | View in SCUBA |
About the gene
| Synonyms | C1orf22 |
|---|---|
| Chromosome | 1: 184690237-184754907 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Unfolded protein response |
Function
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD. May have alpha 1,2-mannosidase activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.