Ubiquitin Protein Quality
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
The module is anchored by HERC4 (HECT E3 ubiquitin ligase), XIAP (IAP family E3 ubiquitin ligase, also anti-apoptotic), and TRIM14 (TRIM family E3 ubiquitin ligase). CHMP7 is an ESCRT-III component involved in membrane scission and protein sorting to lysosomes. EDEM3 is an ER mannosidase that targets misfolded glycoproteins for ERAD. RAB10 is a vesicle trafficking GTPase. GOPC is a Golgi-associated scaffold. Together, multiple E3 ubiquitin ligases, ESCRT machinery, and ERAD components define a protein quality control and ubiquitin-mediated degradation program. Strong coherence with predominantly strong membership supports a coherent program.
Genes
CHMP7, CLCN3, EDEM3, GART, GOPC, HERC4, KRIT1, LRIF1, PCMTD1, POLM, RAB10, SEC22B, SOS1, SUPT20H, THAP5, TOP2B, TRIM14, TTC9C, UTP6, XIAP, ZBED5, ZCCHC7
Most correlated modules
- Interferon Antiviral Response · correlation 0.83
- Chromatin TF Regulation · correlation 0.82
- mRNA Splicing Regulation · correlation 0.79
- mRNA Decay Trafficking · correlation 0.78
- Immune Negative Regulation · correlation 0.78
- T cell Survival · correlation 0.77
- mRNA Splicing · correlation 0.74
- DNA Damage Repair · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.