GOPC — Golgi associated PDZ and coiled-coil motif containing
GOPC belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GOPC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, CLCN3, EDEM3, GART, HERC4, KRIT1, LRIF1, PCMTD1 +13 more | |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, LRBA +14 more | View in SCUBA |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Immune Survival Immune regulation | AGGF1, GRAP2, IRF2, LPAR5, MTAP, PDCD10, SENP7, SYNRG +3 more |
About the gene
| Synonyms | CAL, dJ94G16.2, FIG, GOPC1, PIST |
|---|---|
| Chromosome | 6: 117560269-117602542 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.