HERC4 — HECT and RLD domain containing E3 ubiquitin protein ligase 4
HERC4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HERC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more | View in SCUBA |
| Enterocytes | Basal adhesion remodeling Migration & adhesion | EPB41L2, ETS2, FNDC3B, ITGA6, NT5C2, SESTD1, SGMS1, SH3RF1 +2 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, CLCN3, EDEM3, GART, GOPC, KRIT1, LRIF1, PCMTD1 +13 more | |
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more |
About the gene
| Synonyms | DKFZP564G092, KIAA1593 |
|---|---|
| Chromosome | 10: 67921899-68075301 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Differentiation, Spermatogenesis, Ubl conjugation pathway |
Function
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.