TAF9 — TATA-box binding protein associated factor 9
TAF9 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAF9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE +20 more | View in SCUBA |
About the gene
| Synonyms | AD-004, CGI-137, MGC1603, MGC3647, MGC5067, TAF2G, TAFII31, TAFII32, TAFIID32 |
|---|---|
| Chromosome | 5: 69362026-69370013 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. Essential for cell viability. May have a role in gene regulation associated with apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.