Mitochondrial Ribosome
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 36 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial ribosomal proteins (MRPL4, MRPS18B, MRPS14, MRPL2, MRPS26) with supporting roles from ribosome biogenesis (RSL1D1, PA2G4), RNA processing (SNRPC, DHX9, HNRNPA3), and mitochondrial function (PRDX3, FMC1). Enriched in crypt colonocytes, consistent with high metabolic demand of proliferating crypt cells. Significantly decreased in CD inflammation, suggesting suppression of normal mitochondrial/translational activity during active disease. Neighbor M144 shares mitochondrial components, reinforcing the mitochondrial metabolic theme.
Genes
Most correlated modules
- Mitochondrial Maintenance · correlation 0.92
- Chaperone Proteostasis · correlation 0.91
- ER Stress & UPR · correlation 0.87
- Ribosome Biogenesis · correlation 0.84
- RNA Splicing Regulation · correlation 0.82
- Proteasome Assembly · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.