TDO2 — Tryptophan 2,3-dioxygenase
TDO2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TDO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ALPL, ARL4C, CD44, CHST15, CXCL6, DCBLD1, EVA1A, MAP3K5 +4 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, CHN1, EGFL6, NNMT, PROCR, PRRX1, SERPINF1, TYMP | View in SCUBA |
About the gene
| Synonyms | TDO, TPH2 |
|---|---|
| Chromosome | 4: 155854738-155920406 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
| Biological process | Tryptophan catabolism |
Function
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.