CHN1 — Chimerin 1
CHN1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MHC-II antigen presentation Immune regulation | CD74, CDCA7, FABP5, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA +3 more | View in SCUBA |
| Endothelial | IL33 Alarmin Signaling Inflammation | ARHGAP26, DOC2B, IL33, MCUB, PTAFR, SDCBP, SLC8A1, STMN3 +1 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, EGFL6, NNMT, PROCR, PRRX1, SERPINF1, TDO2, TYMP | View in SCUBA |
About the gene
| Synonyms | ARHGAP2, CHN, DURS2, n-chimerin, RhoGAP2 |
|---|---|
| Chromosome | 2: 174798809-175005381 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
| Biological process | Neurogenesis |
Function
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.