Inflammatory Pericyte Activation
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
This module has the highest inflammation delta (~2.0) and strongest remission reversal, indicating a highly inflammation-induced program. PRRX1 and CDH11 are mesenchymal transcription factor and cadherin marking activated stromal/pericyte state. NNMT drives metabolic reprogramming in CAF-like cells. TDO2 catabolizes tryptophan to kynurenine, creating an immunosuppressive microenvironment. PROCR marks endothelial/pericyte progenitors. TYMP and EGFL6 are pro-angiogenic. SERPINF1 (PEDF) is anti-angiogenic/neuroprotective. CHN1 (α2-chimerin) is a Rho-GAP. Together these define an activated mesenchymal pericyte state with immunomodulatory (TDO2/NNMT) and angiogenic remodeling features — consistent with inflammatory CAF-like pericyte activation.
Genes
CDH11, CHN1, EGFL6, NNMT, PROCR, PRRX1, SERPINF1, TDO2, TYMP
Most correlated modules
- Basement Membrane Remodeling · correlation 0.90
- Complement Regulatory Pericyte · correlation 0.87
- ER Protein Folding · correlation 0.81
- Pericyte Inflammatory Activation · correlation 0.80
- Focal Adhesion Cytoskeleton · correlation 0.78
- Fibrillar Collagen Production · correlation 0.77
- ER Stress Response · correlation 0.77
- Inflammatory ECM Remodeling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.