PRRX1 — Paired related homeobox 1
PRRX1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRRX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Complement-producing Fibroblast Inflammatory | ANK2, C3, CLSTN3, CYP7B1, DAAM1, DHRS3, GUCY1A1, GUCY1B1 +8 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, CHN1, EGFL6, NNMT, PROCR, SERPINF1, TDO2, TYMP | View in SCUBA |
About the gene
| Synonyms | PHOX1, PMX1 |
|---|---|
| Chromosome | 1: 170662728-170739421 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Developmental protein, DNA-binding |
Function
Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.