THAP12 — THAP domain containing 12
THAP12 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THAP12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Membrane Trafficking Protein processing & ER | B4GALT1, BTF3L4, CELF1, CLTC, CSNK1G3, CTBS, DERL2, DYNC1LI2 +23 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4 +18 more | |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | ANAPC5, HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN1 +3 more |
About the gene
| Synonyms | DAP4, P52rIPK, PRKRIR, THAP0 |
|---|---|
| Chromosome | 11: 76349898-76381132 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | DNA-binding |
Function
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.