ER Protein Glycosylation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes PKM, ST13, PRKCSH, RPN2, RPN1, LMAN2 converge on ER protein glycosylation, folding, and quality control. RPN1 and RPN2 are OST complex subunits for N-glycosylation; PRKCSH is glucosidase II beta; LMAN2 is an ER-Golgi lectin; ST13 is an HSP70 co-chaperone. TAPBP (tapasin) also functions in ER peptide loading. PKM is a glycolytic enzyme that may also participate in housekeeping energy supply. Uniform expression across subsets and strong coherence indicate a constitutive housekeeping program.
Genes
ANAPC5, HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN1, RPN2, ST13, TAPBP, THAP12
Most correlated modules
- ER Stress Response · correlation 0.86
- Cellular Housekeeping · correlation 0.86
- Antigen Processing · correlation 0.85
- Actin Cytoskeletal Remodeling · correlation 0.82
- Lymphocyte Trafficking · correlation 0.81
- Chromatin Remodeling · correlation 0.80
- Type I Interferon · correlation 0.76
- RNA Biogenesis & Folding · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.