mRNA Splicing Processing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes RBM15B (m6A mRNA methyltransferase complex writer subunit), SF1 (branch point recognition splicing factor), HNRNPDL (hnRNP RNA binding protein), PNISR (splicing regulator), RSRP1 (arginine/serine-rich splicing), MLLT6 (AF17, chromatin/transcription elongation), and TAPBP (tapasin, MHC-I peptide loading) define a mixed module. RNA splicing and processing genes dominate (RBM15B, SF1, HNRNPDL, PNISR, RSRP1). TAPBP is an outlier suggesting antigen presentation crosstalk. Moderate coherence reflects the mixed nature. REST (transcriptional repressor) and NSD1 (histone methyltransferase) add chromatin regulation. The predominant theme is post-transcriptional RNA processing.
Genes
ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4, LENG8, MAPK8IP3, MLLT6, MORF4L1, NSD1, PBX2, PNISR, RBM15B, REST, RSRP1, SF1, TAPBP, TBC1D14, TBC1D9B, TERF2IP, THAP12, WASHC2C, ZNF639, ZNF655
Most correlated modules
- Translation & Proteostasis · correlation 0.83
- Chromatin Epigenetic Regulation · correlation 0.83
- T Cell Maturation · correlation 0.83
- ER Protein Translocation · correlation 0.82
- T Cell Exhaustion · correlation 0.80
- Histone Demethylase Program · correlation 0.76
- Innate Stress Signaling · correlation 0.75
- T cell Identity Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.