PDAP1 — PDGFA associated protein 1
PDAP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA processing splicing RNA processing | BUD31, DNAJC8, EDF1, EIF2S1, GTF3C6, HPRT1, ILF2, LAMTOR5 +11 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | ATP1B3, MRPL13, NUDC, PTBP1, VDAC2, YWHAE, ZCRB1 | View in SCUBA |
| Endothelial | Rho-Actin Remodeling Cytoskeletal | ANAPC11, ARPC2, ARPC5, ATP6V0B, GNAI2, HNRNPH3, HRAS, KIF5B +9 more | View in SCUBA |
| Gamma-delta T cells | Basal Cell Maintenance Housekeeping | ARHGDIB, CYB561D2, DNAJC8, GPAA1, INO80E, LMF2, MIF4GD, OTUB1 +9 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7 +37 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | ANAPC5, HNRNPM, LMAN2, PKM, PRKCSH, RHOA, RPN1, RPN2 +3 more |
About the gene
| Synonyms | HASPP28, PAP, PAP1 |
|---|---|
| Chromosome | 7: 99392048-99408597 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
Function
Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.