LMAN2 — Lectin, mannose binding 2
LMAN2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LMAN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| CD8⁺ T cells | Vesicle Trafficking Protein processing & ER | AP2M1, ARF1, CDC37, EWSR1, GHITM, GNB2, PPP2CA, RAB11B +1 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, GGCT, MAP2K2, MRPS16, PAICS +10 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB +11 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | ANAPC5, HNRNPM, PDAP1, PKM, PRKCSH, RHOA, RPN1, RPN2 +3 more |
About the gene
| Synonyms | C5orf8, GP36B, VIP36 |
|---|---|
| Chromosome | 5: 177315805-177351840 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high- mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.