RPN1 — Ribophorin I
RPN1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RPN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | UPR / ER Stress Protein processing & ER | CALR, CANX, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5 +10 more | View in SCUBA |
| Gamma-delta T cells | ER Glycoprotein Quality Control Protein processing & ER | APOL2, BAG6, CALR, ELP3, GBP1, GBP2, GBP4, HEXB +9 more | |
| Goblet cells | UPR Chaperone Response Stress | CALR, CRELD2, GMPPB, LRRC59, MANF, NUCB2, P4HB, PDIA3 +2 more | View in SCUBA |
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | ANAPC5, HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN2 +3 more |
About the gene
| Synonyms | OST1 |
|---|---|
| Chromosome | 3: 128619969-128681075 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.