TMEM259 — Transmembrane protein 259
TMEM259 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM259's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CD2, CTDNEP1, DPP7, EIF3D +11 more | |
| Macrophages | General Cellular Maintenance Housekeeping | ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K MAPK Signaling TCR Signaling | AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, GRK2 +11 more |
About the gene
| Synonyms | ASBABP1, C19orf6, MBRL, MGC4022 |
|---|---|
| Chromosome | 19: 1009648-1021179 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.