Mitochondrial Biogenesis
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
This module contains a mix of housekeeping genes. Hub genes include SHFL (antiviral RNA helicase), DPP7 (lysosomal dipeptidyl peptidase), TMEM259 (ER membrane protein), CTDNEP1 (nuclear envelope lipid phosphatase), EIF3D (translation initiation), ATP5MJ and ATP5ME (ATP synthase subunits), OXA1L (mitochondrial inner membrane insertase), RHOT2 (mitochondrial Rho GTPase), and POLRMT (mitochondrial RNA polymerase). In the context of the neighboring OxPhos-heavy modules (M9, M85, M103), the mitochondrial component (ATP5MJ, ATP5ME, OXA1L, RHOT2, POLRMT) is the dominant program. Additional genes (EIF3D, TMEM259, POLR1D, FBL) represent housekeeping RNA/translation programs. CD2 and IRF3 are likely peripheral co-regulated housekeeping genes in T cells. The module is best described as a mixed housekeeping/mitochondrial module, with mitochondrial biogenesis being the strongest signal.
Genes
ANKRD13D, ATP5ME, ATP5MJ, CAMTA1, CD2, CTDNEP1, DPP7, EIF3D, FBL, IRF3, MESD, OXA1L, POLR1D, POLRMT, RGS14, RHOT2, SEPTIN1, SHFL, TMEM259, VPS51
Most correlated modules
- Basal Cell Maintenance · correlation 0.84
- TCR Vesicular Trafficking · correlation 0.83
- ATP Synthase Complex · correlation 0.83
- RNA Splicing Processing · correlation 0.81
- Mitochondrial Dynamics · correlation 0.79
- NKG2D Cytotoxic Activation · correlation 0.79
- Mitochondrial Housekeeping · correlation 0.78
- RNA Processing · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.