GRK2 — G protein-coupled receptor kinase 2

GRK2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GRK2's module in each cell type

Cell type	Module	Shares the module with
Gamma-delta T cells	GPCR-AKT-MAPK Signaling TCR Signaling	ADNP, AKT1, ALYREF, B3GALT6, BRD4, BRI3, BTBD6, CENPB +29 more
Innate lymphoid cells	AP-1 Transcriptional Activation DNA regulation & transcription	AHNAK, ALYREF, CD81, CDV3, CITED4, ESYT2, ETS1, GNAI2 +28 more	View in SCUBA
Macrophages	Retromer Endosomal Sorting Vesicular traficking	ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more	View in SCUBA
Mucosal-associated invariant T cell	PI3K MAPK Signaling TCR Signaling	AKT1, APH1A, BRD4, CALM2, CMTM3, DAZAP1, GNAS, MAP2K2 +11 more

About the gene

Synonyms	ADRBK1, BARK1
Chromosome	11: 67266473-67286556
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Kinase, Serine/threonine-protein kinase, Transferase

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). Inhibits relaxation of airway smooth muscle in response to blue light.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.