Mature colonocyte metabolism
Gene co-expression module in Enterocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 15 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
BTNL3, XDH, ASS1, CORO2A, TMEM45B, SLC25A37 and PLEKHS1 mark mature colonocytes toward the surface. XDH (purine catabolism), ASS1 (arginine synthesis) and SLC25A37 (mitochondrial iron import) define a metabolic signature. ATP1B3 supports basolateral transport, and BTNL3 is a surface epithelial butyrophilin that regulates intraepithelial gamma-delta T cells.
Genes
ANXA4, ASS1, ATP1B3, BTNL3, CORO2A, HMCN2, MGAT4A, MOB3B, MTUS1, PLEKHS1, PRSS12, RIN2, SLC25A37, TMEM45B, XDH
Most correlated modules
- YAP cytoskeletal remodeling · correlation 0.75
- Colonocyte differentiation signaling · correlation 0.73
- Colonocyte terminal differentiation · correlation 0.71
- Core energy metabolism · correlation 0.65
- Apical junction complex · correlation 0.61
- Serotonergic receptor signaling · correlation 0.56
- Inflammatory cell death · correlation 0.54
- Apicobasal polarity scaffold · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.