Endosomal Vesicle Trafficking
Gene co-expression module in Colonocytes
| Category | Secretion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes MYL12B and MYL12A (non-muscle myosin light chains) co-occur with CHMP5 and CHMP2B (ESCRT-III complex for endosomal membrane scission), RAB7A (late endosome identity GTPase), VAMP8 (vesicle-associated membrane protein for exocytic/endosomal fusion), and MAL2 (membrane raft protein involved in transcytosis). ACTB, CAP1, and TMSB4X provide actin dynamics supporting vesicle motility. This is a coherent endosomal vesicular trafficking program. The neighbor relationship with M79 (which shares ESCRT member CHMP2A and lysosomal genes) confirms a broader vesicular sorting neighborhood; M75 is the endosomal/exocytic arm while M79 is the lysosomal/autophagic arm.
Genes
Most correlated modules
- Lysosomal Autophagy Trafficking · correlation 0.95
- Epithelial Junction Integrity · correlation 0.94
- Senescent Stress Signaling · correlation 0.92
- mTOR Lysosomal Sensing · correlation 0.92
- Arp2/3 Actin Branching · correlation 0.92
- Senescent Surface Identity · correlation 0.90
- TNF Apoptosis Resistance · correlation 0.90
- Integrin Adhesion Signaling · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.