TMEM98 — Transmembrane protein 98
TMEM98 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM98's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ALDH1A1, ALDH3A2, ASGR1, ATP9A, BMP2K, DSP, FAM107B, KIAA1522 +12 more | View in SCUBA |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9 +5 more | View in SCUBA |
About the gene
| Synonyms | DKFZP564K1964 |
|---|---|
| Chromosome | 17: 32927910-32945106 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
Function
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.