Lysosomal-secretory processing
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes split between ER/glycosylation-secretory machinery (RPN2 oligosaccharyltransferase, PIGT GPI-transamidase, COPZ1 COPI) and the endo-lysosomal compartment (SCARB2, LAMP1, CTSL), with a clear mechanotransduction arm (TEAD1, WWTR1/TAZ, ZYX, PLOD2, TMEM98) — PLOD2, CTSL and ZYX are canonical YAP/TAZ targets in mural/fibroblast cells. Strong coherence and uniform expression argue for a genuine biosynthetic/degradative secretory program in SMCs rather than contamination; the TEAD1/WWTR1 axis likely acts as the shared upstream driver linking it to the other protein-handling modules in this neighborhood.
Genes
BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9, RPN2, SCARB2, TEAD1, TMEM98, WWTR1, ZYX
Most correlated modules
- Generic maintenance transcripts · correlation 0.88
- Costameric cytoskeleton · correlation 0.88
- Adhesion Activation · correlation 0.87
- Wnt-Hedgehog Niche · correlation 0.85
- Fibroblast Matrisome · correlation 0.84
- SMC Phenotype Regulation · correlation 0.82
- Matrisome Regulators · correlation 0.74
- Ribonucleoprotein & translation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.