TNFRSF10A — TNF receptor superfamily member 10a
TNFRSF10A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF10A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more | View in SCUBA |
| Endothelial | TRAIL-mediated Apoptosis Stress | CLDN15, ELOVL7, EVA1C, FGD4, ISCU, LMCD1, SELENOM, TIMMDC1 +2 more | View in SCUBA |
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, FHL3, GABARAPL2, LDLRAP1, LY6E, PDGFB, PLSCR3, SGSM3 +4 more |
About the gene
| Synonyms | Apo2, CD261, DR4, TRAILR-1, TRAILR1 |
|---|---|
| Chromosome | 8: 23190452-23225102 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.