TNFRSF9 — TNF receptor superfamily member 9
TNFRSF9 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB +13 more | View in SCUBA |
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3 +9 more | View in SCUBA |
| Gamma-delta T cells | Effector Cytokine Secretion Inflammation | APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more |
About the gene
| Synonyms | 4-1BB, CD137, ILA |
|---|---|
| Chromosome | 1: 7915871-7943165 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
Function
Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.