UBA52 — Ubiquitin A-52 residue ribosomal protein fusion product 1
UBA52 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBA52's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Translation Initiation RNA processing & translation | BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more | |
| Glial cells | Nascent Polypeptide Translation RNA processing & translation | BTF3, EEF1A1, EIF3K, ERH, FAU, LGALS3, NACA, NDUFA4 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Translation Elongation RNA processing & translation | BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, FTL +8 more | |
| Neutrophils | Translational Housekeeping Housekeeping | COX4I1, EEF1A1, EEF1B2, GSTP1, MGST1, NPM1, RACK1, YBX1 |
About the gene
| Synonyms | CEP52, HUBCEP52, L40, MGC126879, MGC126881, MGC57125, RPL40 |
|---|---|
| Chromosome | 19: 18571730-18577550 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, Ribosomal protein |
Function
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell- cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.