Nascent Polypeptide Translation
Gene co-expression module in Glial cells
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes BTF3, NACA, RACK1, UBA52, FAU, and EIF3K are all directly involved in ribosome function, nascent polypeptide handling, and translation initiation. NACA is the nascent polypeptide-associated complex alpha subunit, RACK1 is a ribosomal scaffold protein, UBA52 and FAU encode ubiquitin-ribosomal protein fusions, and EIF3K is a translation initiation factor. SUMO2 participates in post-translational modification linked to translational quality control. Strong coherence, high detection rate, and uniform expression across subsets confirm a core housekeeping/translational program rather than a cell-state-specific signature.
Genes
BTF3, EEF1A1, EIF3K, ERH, FAU, LGALS3, NACA, NDUFA4, RACK1, SUMO2, UBA52
Most correlated modules
- Mitochondrial OxPhos Integrity · correlation 0.93
- Rho GTPase Signaling · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.92
- ER Translocon Activity · correlation 0.90
- Proteasomal Proteostasis · correlation 0.89
- Proteostasis Stress Response · correlation 0.88
- Oxidative Stress Response · correlation 0.88
- ER-Mitochondria Housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.