UBAC2 — UBA domain containing 2
UBAC2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBAC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC +13 more | View in SCUBA |
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
About the gene
| Synonyms | FLJ30548, PHGDHL1, RP11-178C10.1 |
|---|---|
| Chromosome | 13: 99200774-99386504 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Wnt signaling pathway |
Function
Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.