UGDH — UDP-glucose 6-dehydrogenase
UGDH belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UGDH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5 +8 more | View in SCUBA |
About the gene
| Chromosome | 4: 39498755-39528311 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Allosteric enzyme, Oxidoreductase |
| Biological process | Carbohydrate metabolism |
Function
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity). Required for proper brain and neuronal development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.