FABP2 — Fatty acid binding protein 2
FABP2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FABP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Chylomicron lipid absorption Lipid metabolism | ACO2, ALDOB, ANPEP, CNDP2, DGAT1, ENPEP, MOGAT2, MTTP +3 more | View in SCUBA |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ACLY, ASPH, C9orf152, CKAP4, ESRP1, IL13RA1, PLPP5, RAB2A +8 more | View in SCUBA |
About the gene
| Synonyms | I-FABP |
|---|---|
| Chromosome | 4: 119317250-119322138 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transport |
Function
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.