MITF Lysosomal Program
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 34 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include ARSB (arylsulfatase B, lysosomal enzyme degrading glycosaminoglycans), MITF (master transcription factor for lysosome biogenesis and melanocyte/macrophage identity), OSBPL3/OSBPL9 (oxysterol-binding proteins, lipid transport at endosomes), CERS6 (ceramide synthase, sphingolipid metabolism), CHST11 (chondroitin sulfate sulfotransferase), WDFY2 (FYVE domain endosomal protein), PTPRJ (receptor phosphatase, macrophage signaling), ABHD3 (phospholipase). MITF is a known master regulator of lysosome biogenesis (CLEAR network) and macrophage identity. ARSB is a direct lysosomal enzyme. OSBPL proteins and CERS6 link to lipid handling at the endolysosomal compartment. Several genes enriched in mono_mac. This module best represents a lysosomal/lipid metabolism program driven by MITF.
Genes
ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4, FBXL20, FCHSD2, FMNL2, ITFG1, MAML2, MAP3K5, MBD5, MBNL2, MITF, OSBPL3, OSBPL9, PARN, PARP8, PHTF2, PIAS2, PRKCH, PRKD3, PTPRJ, SLC38A9, TAF2, TANC2, UBE2E1, USP25, VPS35L, WDFY2, ZNF438
Most correlated modules
- Rho GTPase Signaling · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.97
- Innate Immune Dampening · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- DNA Damage Response · correlation 0.95
- Golgi Vesicle Trafficking · correlation 0.95
- Rho GTPase Signaling · correlation 0.94
- Endosomal Rab Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.