Chromatin Regulation
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs include chromatin/DNA regulators HMGN1 (nucleosome binding), HDAC1 (deacetylase), PARP1 (DNA damage/chromatin), and IMP4 (rRNA processing). Mixed with metabolic enzymes (GRHPR, NANS, SEPHS2, LYPLA1, GCHFR) and BIK (apoptosis), METAP2. The most connected coherent biological theme combining HMGN1+HDAC1+PARP1 is chromatin regulation, consistent with neighbor module M20 which is also chromatin-associated. Supports a shared nuclear chromatin program across this neighborhood.
Genes
BIK, DSTN, GCHFR, GRHPR, HDAC1, HMGN1, IMP4, LYPLA1, METAP2, NANS, PARP1, SEPHS2
Most correlated modules
- Chromatin Remodeling · correlation 0.93
- mRNA Splicing · correlation 0.93
- Somatic Hypermutation · correlation 0.88
- Cell Cycle G1/S · correlation 0.88
- Germinal Center Maturation · correlation 0.87
- Actin Cytoskeleton · correlation 0.82
- Actin cytoskeleton remodeling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.