NANS — N-acetylneuraminate synthase
NANS belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NANS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | BIK, DSTN, GCHFR, GRHPR, HDAC1, HMGN1, IMP4, LYPLA1 +3 more | View in SCUBA |
| Goblet cells | ER Chaperone Glycosylation Protein processing & ER | ANG, ATP6V1G1, CD63, FKBP2, OST4, PPIC, RABAC1, REEP5 +4 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A +8 more | View in SCUBA |
About the gene
| Synonyms | SAS |
|---|---|
| Chromosome | 9: 98056732-98083077 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N- acetylneuraminate-9-phosphate (Neu5Ac-9-P). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9- phosphate (KDN-9-P). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively. Required for brain and skeletal development
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.