mRNA Splicing
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes combine RNA-processing splicing factors (SRSF9, HNRNPC, HNRNPK), mitochondrial carriers (SLC25A5/ANT2, SLC25A3 phosphate carrier), topoisomerase TOP1, glycolytic/PPP TKT, clathrin CLTA, RAC1, FKBP1A. Mixed housekeeping/metabolic module but the highest PageRank hub is a splicing factor with two additional hnRNPs, pointing to RNA processing as the leading coherent program, though metabolic carriers dilute it.
Genes
CLTA, FKBP1A, HNRNPC, HNRNPK, RAC1, SLC25A3, SLC25A5, SRSF9, TKT, TOP1
Most correlated modules
- Chromatin Remodeling · correlation 0.96
- Oxidative Phosphorylation · correlation 0.95
- Mitochondrial Redox · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Spliceosome snRNP · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- Chromatin Regulation · correlation 0.93
- Proteasome Complex · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.