Actin Cytoskeleton
Gene co-expression module in CD19⁺ B cells
| Category | Cytoskeletal |
|---|---|
| Genes | 23 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 23 genes have a known function matching the annotation |
Why this annotation
Module is dominated by actin cytoskeleton and Arp2/3 complex genes: ARPC2, ACTR3, ARPC1B, ARPC4, ARPC5, BRK1 (Arp2/3 / WAVE), CORO1A, TWF2, MYL6, CAP1, ACTB, PFN1, ACTG1, RHOA, LCP1, CAPZB, WDR1. This is a clear actin cytoskeleton/cell motility program, relevant to leukocyte migration. Core coherence, uniform expression.
Genes
ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1, CAP1, CAPZB, CHMP2A, CORO1A, DBI, GDI2, LCP1, MYL6, PFN1, RHOA, TRAPPC1, TWF2, VAMP8, WDR1, YWHAB
Most correlated modules
- Actin Cytoskeleton · correlation 0.96
- Oxidative Phosphorylation · correlation 0.94
- Oxidative Phosphorylation · correlation 0.92
- Actin Cytoskeleton · correlation 0.91
- mRNA Splicing · correlation 0.91
- Oxidative Phosphorylation · correlation 0.90
- Glycolysis OxPhos · correlation 0.87
- Oxidative Phosphorylation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.