IMP4 — IMP U3 small nucleolar ribonucleoprotein 4
IMP4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IMP4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | BIK, DSTN, GCHFR, GRHPR, HDAC1, HMGN1, LYPLA1, METAP2 +3 more | View in SCUBA |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | BXDC4, MGC19606 |
|---|---|
| Chromosome | 2: 130342877-130347967 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein |
| Biological process | Ribosome biogenesis, rRNA processing |
Function
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.