Actin cytoskeleton remodeling
Gene co-expression module in CD19⁺ B cells
| Category | Cytoskeletal |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes center on actin cytoskeleton and BCR signaling adaptors: ACTR2 (Arp2/3 complex), CAPZA1 (actin capping), LIMS1, RFTN1 (raftlin, lipid raft for BCR), RAP1B, HCLS1 (HS1 actin regulator in lymphocytes), GRB2/SKAP2 (signaling adaptors), BASP1. This is an actin remodeling / immune synapse program coupled to BCR signaling. Some translation genes (EIF3A, NOP58) are peripheral. Predominantly cytoskeletal organization supporting B-cell receptor signaling/migration.
Genes
ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, HCLS1, LIMS1, NOP58, OTULIN, PTP4A2, PTPN18, PXK, RAP1B, RFTN1, SKAP2, TACC1
Most correlated modules
- B-cell activation signaling · correlation 0.86
- Actin Cytoskeleton · correlation 0.85
- Somatic Hypermutation · correlation 0.83
- Germinal Center Maturation · correlation 0.82
- Chromatin Regulation · correlation 0.82
- BCR Ras signaling · correlation 0.78
- B cell activation · correlation 0.77
- Actin Cytoskeleton · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.