Mitochondrial Redox
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are mitochondrial antioxidant peroxiredoxins (PRDX3, PRDX2) and redox/iron-sulfur cluster proteins (GLRX5), plus mitoribosomal proteins (MRPL51, MRPL37) and NAA38. The dominant theme is mitochondrial redox/antioxidant defense within a mitochondrial maintenance program.
Genes
COMTD1, GLRX5, MRPL37, MRPL51, NAA38, PRDX2, PRDX3, PTTG1, RBX1, SRP9
Most correlated modules
- Chromatin Remodeling · correlation 0.98
- RNA Processing · correlation 0.97
- Oxidative Phosphorylation · correlation 0.96
- Proteasome Complex · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
- Spliceosome snRNP · correlation 0.95
- Cell Cycle Proliferation · correlation 0.95
- Glycolysis Biosynthesis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.