Oxidative Phosphorylation
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are glycolytic/metabolic and oxidative phosphorylation components: GAPDH, TALDO1 (transaldolase, PPP), PMVK (mevalonate), plus a strong OxPhos signature COX8A, NDUFB10, ATP5F1C, ATP5F1A, NDUFB8. Combined with housekeeping ubiquitin/proteasome (UBE2L3, SUMO2, ANAPC11, SEM1) and vesicle/trafficking (AP2S1, COPE, GNG5). The dominant coherent theme across hubs is mitochondrial energy metabolism with several ETF/ATP synthase subunits. Uniform expression, core coherence, no contamination.
Genes
ANAPC11, AP2S1, ATP5F1A, ATP5F1C, COPE, COX8A, GAPDH, GNG5, NDUFB10, NDUFB8, PMVK, PPP1CA, SEM1, SUMO2, TALDO1, UBE2L3
Most correlated modules
- Oxidative Phosphorylation · correlation 0.99
- Oxidative Phosphorylation · correlation 0.98
- Spliceosome snRNP · correlation 0.96
- Mitochondrial Redox · correlation 0.96
- Proteasome Complex · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- Glycolysis OxPhos · correlation 0.95
- RNA Processing · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.