Proteasome Complex
Gene co-expression module in CD19⁺ B cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are proteasome subunits (PSMD2, PSMD14, PSMD7, PSMB7) and DNA repair/Ku complex (XRCC5, XRCC6, RNASEH2C). Combined with mitoribosomal proteins (MRPS18C, MRPL22) and HPRT1 (nucleotide salvage), this represents protein degradation/proteostasis machinery. Proteasome subunits dominate by count and centrality.
Genes
HPRT1, MRPL22, MRPS18C, PIN1, PSMB7, PSMD14, PSMD2, PSMD7, RAB8A, RNASEH2C, XRCC5, XRCC6
Most correlated modules
- RNA Processing · correlation 0.98
- Spliceosome snRNP · correlation 0.97
- Oxidative Phosphorylation · correlation 0.96
- Mitochondrial Redox · correlation 0.96
- Chaperonin Protein Folding · correlation 0.96
- Glycolysis Biosynthesis · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
- Mitochondrial Translation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.