Cell Cycle Proliferation
Gene co-expression module in CD19⁺ B cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes CENPW, MAD2L1, BIRC5, BUB3, CEP55 are mitotic/cell cycle regulators; DTYMK and DUT are nucleotide metabolism for DNA synthesis. Core coherent module of proliferation genes in B cells (proliferating germinal center/plasmablast precursors). Upregulated in inflammation, consistent with proliferating B cell populations.
Genes
ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CENPW, CEP55, CKS1B, DTYMK, DUT, MAD2L1, PHF19, TUBB
Most correlated modules
- DNA Replication · correlation 0.98
- RNA Processing · correlation 0.96
- Mitochondrial Redox · correlation 0.95
- Chromatin Remodeling · correlation 0.95
- Proteasome Complex · correlation 0.95
- Cell Cycle G1/S · correlation 0.94
- Mitotic Spindle · correlation 0.94
- DNA Replication · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.