RNA Processing
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Mixed proliferation-associated module. Contains LSm/snRNP splicing factors (SNRNP25, SNRNP40, LSM3, LSM5, LSM4, POP7), nuclear transport (RANBP1), DNA replication/repair (RPA3, POLD2-like, CENPX, CDK4), proteasome (PSMC3), and ribosome biogenesis (PA2G4, ANP32A). The recurring theme across these is a proliferating-cell biosynthetic/RNA-processing program, with strongest hub centrality on RNA processing factors. Given mixed nature and cell-cycle genes (CDK4, CENPX, PTTG-like), but RNA processing hubs dominate.
Genes
ANP32A, CCDC167, CDK4, CENPX, CYC1, FDPS, GGCT, LSM3, LSM4, LSM5, MRPS16, NAA50, NDUFV1, NUDT1, PA2G4, POLR3K, POP7, PPM1G, PSMC3, RANBP1, RPA3, SNRNP25, SNRNP40
Most correlated modules
- Proteasome Complex · correlation 0.98
- Mitochondrial Redox · correlation 0.97
- Glycolysis Biosynthesis · correlation 0.97
- Spliceosome snRNP · correlation 0.96
- Cell Cycle Proliferation · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
- Chromatin Remodeling · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.