Spliceosome snRNP
Gene co-expression module in CD19⁺ B cells
| Category | RNA processing |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by spliceosomal Sm proteins (SNRPB, SNRPE, SNRPD1, SNRPF, SNRPG, SNRPC) and RNA processing/transport factors (RAN, YBX1, MAGOH). Mitochondrial members (CHCHD2, COX7B, GHITM) and PPIA are peripheral. The core program is small nuclear ribonucleoprotein assembly / mRNA splicing.
Genes
CHCHD2, COX7B, GHITM, MAGOH, PPIA, RAN, SNRPB, SNRPC, SNRPD1, SNRPE, SNRPF, SNRPG, YBX1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.98
- Glycolysis OxPhos · correlation 0.97
- Glycolysis Biosynthesis · correlation 0.97
- Proteasome Complex · correlation 0.97
- Oxidative Phosphorylation · correlation 0.96
- RNA Processing · correlation 0.96
- Chaperonin Protein Folding · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.