Glycolysis Biosynthesis
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes are glycolytic enzymes (PKM, TPI1, LDHA) and nucleotide biosynthesis (PAICS), plus MDH1 (malate-aspartate shuttle). Combined with FABP5 (lipid), TUFM/MRPL17 (mitochondrial translation), TRAP1 (mito HSP90), PRDX1 (redox). This is a biosynthetic/glycolytic metabolic program characteristic of activated/proliferating cells.
Genes
EIF3I, FABP5, LDHA, MDH1, MRPL17, PAICS, PKM, POLD2, PRDX1, PSMG1, TPI1, TRAP1, TUFM
Most correlated modules
- Mitochondrial Translation · correlation 0.98
- Nucleotide Metabolism Biosynthesis · correlation 0.97
- Spliceosome snRNP · correlation 0.97
- Glycolysis OxPhos · correlation 0.97
- RNA Processing · correlation 0.97
- Chaperonin Protein Folding · correlation 0.96
- Proteasome Complex · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.