GLRX5 — Glutaredoxin 5
GLRX5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GLRX5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Mitochondrial Redox Mitochondrial & OxPhos | COMTD1, MRPL37, MRPL51, NAA38, PRDX2, PRDX3, PTTG1, RBX1 +1 more | View in SCUBA |
| Endothelial | mRNA Splicing RNA processing & translation | DIAPH1, EIF4A3, FUBP1, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1, MAGOH +8 more | View in SCUBA |
| Goblet cells | SR Splicing Factors RNA processing & translation | CLTA, MLEC, NDUFAB1, PPP1R14B, SRSF2, SRSF9, TRIR, UQCRFS1 +1 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, IER3IP1 +30 more | View in SCUBA |
| Smooth muscle cells | Lipid Kinase Signaling Housekeeping | ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DGKD, DNTTIP2, FCHSD2 +10 more | View in SCUBA |
About the gene
| Synonyms | C14orf87, GRX5, PR01238 |
|---|---|
| Chromosome | 14: 95533503-95544724 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer. Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion. Required for normal regulation of hemoglobin synthesis by the iron- sulfur protein ACO1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.