Oxidative Phosphorylation
Gene co-expression module in CD19⁺ B cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by oxidative phosphorylation complex subunits: ATP synthase (ATP5MF, ATP5PF, ATP5MC3, ATP5PB), cytochrome c oxidase (COX5A), complex III (UQCR10), complex I (NDUFA12, NDUFAB1, NDUFB3). Combined with proteasome subunits (PSMB3, PSMB2, PSMA4, PSMA1) and spliceosome (SNRPD3), this is a metabolic/housekeeping module centered on OxPhos. The OxPhos genes dominate by PageRank.
Genes
ATP5MC3, ATP5MF, ATP5PB, ATP5PF, COX5A, ELOB, ERH, LDHB, NDUFA12, NDUFAB1, NDUFB3, PSMA1, PSMA4, PSMB2, PSMB3, SNRPD3, UQCR10
Most correlated modules
- Oxidative Phosphorylation · correlation 0.99
- Oxidative Phosphorylation · correlation 0.98
- Glycolysis OxPhos · correlation 0.98
- Spliceosome snRNP · correlation 0.98
- Proteasome Complex · correlation 0.96
- Mitochondrial Redox · correlation 0.96
- Glycolysis Biosynthesis · correlation 0.96
- Mitochondrial Translation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.