LIG1 — DNA ligase 1
LIG1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ATAD2, ATAD5, BRCA1, CDCA4, E2F8, ESCO2, FANCI, FBXO5 +4 more | View in SCUBA |
| CD8⁺ T cells | DNA Replication Fork Cell cycle | CDC6, CDT1, CHAF1A, CTNNAL1, DHFR, DUT, FEN1, PCNA +5 more | View in SCUBA |
| Endothelial | S-phase DNA Replication Cell cycle | CHEK1, DNAJC9, FANCA, HELLS, MCM7, PCNA, RFC4, WDR76 | View in SCUBA |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CENPM, CLSPN, DNAJC9, FANCI, PKMYT1, RRM1 | View in SCUBA |
| Natural Killer cells | DNA Replication Cell cycle | ATAD2, DHFR, FEN1, MCM7, PCNA, TK1, TMEM106C, UHRF1 | View in SCUBA |
About the gene
| Synonyms | hLig1, LIGI |
|---|---|
| Chromosome | 19: 48115445-48170603 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication |
Function
DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.