T cell exhaustion
Gene co-expression module in CD4⁺ T cells
| Category | Exhaustion |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
Checkpoint/exhaustion markers dominate: LAG3 (core inhibitory receptor), CD38 (activation/exhaustion), CD247 (CD3 zeta), LRBA (CTLA-4 trafficking), RAB27A. Combination of LAG3 + CD38 + LRBA indicates a chronically activated/exhausted CD4 T cell state, consistent with inflamed IBD tissue.
Genes
CD247, CD38, CD59, FLT1, GAN, IKBKB, LAG3, LRBA, PTMS, RAB27A, TMBIM6, WSB2
Most correlated modules
- MAF regulatory program · correlation 0.82
- T-cell activation · correlation 0.81
- Activated effector Tcell · correlation 0.79
- Integrin Rap1 Signaling · correlation 0.75
- Tfh IL21 help · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.